Background: Despite the undeniable significance of blood transfusion in saving a millions life in emergencies and\nmedical treatment, the quality of blood faced challenges from transfusion-transmitted infections (TTIs) such as HIV\n(human immunodeficiency virus), HBV (hepatitis B virus) and HCV (hepatitis C virus). This cross-sectional study was\nundertaken with the aim of determining the seroprevalence and risk factors of HIV, HBV, and HCV among blood\ndonors.\nMethods: An institutional based cross-sectional study was conducted at Debre Tabor district hospital from January\n2017 to February 2018. Blood samples from volunteer donors collected; serum separated and screened with ELISA\ntests for detection of anti-HIV, hepatitis-B surface antigen (HBsAg) and anti-HCV. Fishersâ?? exact test was employed to\nsee the association between variables as well logistic regression tests were applied to identify potential risk factors.\nP-value of less than 0.05 was considered as statistically significant.\nResult: A total of 310 volunteer donors were included in the study. The proportion of blood donors having at least\none viral-TTI was 12.6% while the magnitudes of HIV, HBV, and HCV were 2.6, 5.8 and 4.2%, respectively. Educational\nstatus and multiple sexual behaviors are significantly associated with HIV acquisition whilst marital status was\nsignificantly associated with HBsAg seropositivity.\nConclusion: Seroprevalence of transfusion-transmissible infections was high and alarming therefore proper\nscreening of donated blood with test methods having better diagnostic performance should be employed. Also\nencouragement of blood donation from voluntary donors and creating awareness on the general public regarding\nHIV, HBsAg and HCV transmission and prevention should be strengthen.
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